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Call your doctor at once if you have any of these serious side effects: sleep problems insomnia nervous or irritable fever, hot flashes, changes in your menstrual appetite changes, weight Less desconto levothroid serious side effects may include mild hair loss. Patients with nontoxic diffuse goiter or nodular thyroid disease Exercise caution when administering levothyroxine to patients with nontoxic diffuse goiter or nodular thyroid disease in order to prevent precipitation of thyrotoxicosis see WARNINGS. Thyrotoxicosis may result in the growth of goiters and or hypothyroidism. Many people using this medication do not have serious side effects. It may several weeks before you notice change in your symptoms. Pregnancy of proper amounts of thyroid hormone during pregnancy has not been shown to cause birth defects or other problems. An inadequate response to daily doses 300 mcg day is rare and may indicate poor compliance, malabsorption, and or drug interactions.