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This drug may make you dizzy or use caution engaging in activities requiring alertness such as driving or using machinery. We continue to focus on working towards expanding our product offering as quickly and effectively as possible. Home Site Map About Us Disclaimer Contact Prostate Cancer Research Institute PCRI Material provided by PCRI is intended for educational purposes for discussion with your physician and should not be considered as medical advice. How does IGF-1 stimulate osta casodex ilma arsti the survival of prostate cancer cells? When IGF-1 binds to its receptor on the surface of the prostate cells, it triggers changes in protein phosphorylation that lead to the activation of protein called Akt.